HUMAN BREAST TISSUE LYSATE

 Sample Lung
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Diagnosis: Infiltrating ductal carcinoma.
   
Sex: Female
Age: 39
Grade: 2
Stage: IIB, T2N1M0  
Catalog Number:

Extraction 1, soluble protein fraction

T2-008-T-1

Human breast tumor tissue lysate

1 mg/ml, 100 µg/vial

T2-008-N-1

Human breast normal tissue lysate (matched)

1 mg/ml, 100 µg/vial

 

Extraction 2, insoluble protein fraction

T2-008-T-2

Human breast tumor tissue lysate

1 mg/ml, 100 µg/vial

T2-008-N-2

Human breast normal tissue lysate (matched)

1 mg/ml, 100 µg/vial

PATHOLOGY DATA

  
Location:              Right breast.  
   
Gross findings:

Tumor size 4 cm, ill demarcated.

Cut section firm and white.

Ipsilateral axillary lymph nodes examined:      10
   
Microscopic findings:

The tumor is composed of proliferation of malignant epithelial cells. The epithelial cells are arranged as lines and groups invading the stroma. The tumor cells have irregular, basophilic nuclei and abundant cytoplasm. Nuclear chromatin is coarse with prominent nuclei. Mitotic figures are evident. Some areas show microinvasions.  The stroma is infiltrated by small numbers of chronic inflammatory cells. Necroses are seen, but blood vessel invasion is not seen. The lymph nodes show metastasis (6/10).
   
Histologic pattern:

Cell distribution:

+/-

 

Structure / Pattern:

+/-

Diffuse:

-

 

Streaming:

-

Mosaic:

+

 

Storiform:

-

Necrosis:

-

 

Fibrosis:

-

Lymphocytic infiltration:

+

 

Pallisading:

-

Vascular invasion:

-

 

Cystic degeneration:

-

Clusterized:

+

 

Bleeding:

+

Alveolar formation:

+

 

Myxoid change:

-

Indian file:

-

 

Psammoma body:

-
   
Cellular differentiation:

Squamous:

+/-

 

Adenomatous:

+/-

 

Sarcomatous:

+/-

Squamoid:

-

 

Glandular cell:

+

 

Round cell:

-

Spindle:

-

 

Cell stratification:

+

 

Spindle cell:

-

Keratin:

-

 

Secretion:

+

 

Leiomyoblast:

-

Desmosome:

-

 

Intracellular vacuole:

+

 

Lipoblast:

-

Pearl:

-

 

Glandular formation:

+

 

Rhadomyoblast:

-
   
Nuclear atypia:

Nuclear Appearance:

0

I

II

III

Anisonucleosis:

 

 

X

 

Hyperchromatism:

 

 

X

 

Nucleolar prominent:

 

 

X

 

Multinucleated giant cell:

 

X

 

 

Mitotic activity:

 

 

X

 

Nuclear grade:

 

 

X

 
   
Source:

Integrated Laboratory Services-Biotech (ILSbio), Chestertown, MD 21620 www.ilsbio.com
ILS-1476

     
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